Discard tautomers with violated hybridization
geometries
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If checked, tautomers with atom hybridization states that
require a different spatial distribution of the neighbor atoms than
the given one are discarded (e.g. sp
2
requires a trigonal planar
arrangement of the neighbors but the given arrangement is trigonal
pyramidal). The setting has only an effect if atom 3D coordinates
are available. (default: enabled)
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Discard tautomers with sp
3
atoms in planar rings
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If checked, tautomeric forms of a molecule with sp
3
atoms in
rings that have been perceived as aromatic in the start tautomer
are discarded. (default: enabled)
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Discard tautomers with non-unique pharmacophores
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If checked, each generated tautomer with a molecule
pharmacophore that is identical to a pharmacophore of a previous
tautomeric form is discarded. (default: disabled)
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