Orally bio-available: Palm filters
This settings are based on the first study in which dynamic surface properties of drug molecules are correlated with drug absorption. The results suggest that the PSA (Polar Surface Area) is a better descriptor of intestinal drug absorption than log P.
Drugs with PSA > 139 A² will be < 10% absorbed while drugs with PSA < 63 A² will be completely absorbed.
- PSA max. 140 A²: orally bioavailable
- PSA max. 63 A²: strictly orally bioavailable
Palm, Katrin; Luthman, Kristina; Ungell, Anna-Lena; Strandlund, Gert; Artursson, Per.
Correlation of Drug Absorption with Molecular Surface Properties.
Journal of Pharmaceutical Sciences (1996), 85(1), 32-9.
Palm, Katrin; Stenberg, Patric; Luthman, Kristina; Artursson, Per.
Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans.
Pharmaceutical Research (1997), 14(5), 568-571.