Expert Consulting Services to Inspire the Innovative Process
Inte:Ligand is specialized in advancing your drug discovery journey. We guide you through Hit Identification and the Hit to Lead and Lead Optimization phases, ensuring that your promising compounds are refined for maximum efficacy and safety.
Partner with us to accelerate your research and bring your pharmaceutical innovations to life.
Our unique advanced Pharmacophore Technology, enables
- Identification of essential molecular features crucial for data mining and effective drug design.
- Integration of our unique technology with physics based approaches as well as AI and machine learning generative approaches tailored to your specific research needs
- Unique cutting-edge Virtual Screening techniques to streamline the identification of potential drug candidates.
Find our more about our products.
Our expertise lies in computer-aided molecular design, molecular modeling and medicinal chemistry and more than 30 years experience in providing research consulting services for life science industries.
- Pharmaceutical
- Biotechs and SMEs
- MedChem CROs
- Cosmetic
- Food and Flavorings
- Animal Health
- Crop Protection
Partner with us to accelerate your research and bring your pharmaceutical innovations to life.
Services and Solutions Overview
Flexible Models & Rapid Turnaround for Contract Research.
We offer highly flexible Contract Research (CR) license models designed to fit seamlessly into your project timelines and deliver results in the fastest possible timeframes.
- With extensive experience in CR research and an extensive portfolio of services and solutions, we customize our services for your target product profile and project needs.
- We have established license models with preferred partners to establish end to end discovery workflow if needed.
Our Virtual Screening Collections
To support our clients virtual screening needs, we have a collection of approximately 600 million compounds originating from different providers known for reliability and high quality.
We offer screening of fragment, natural products, and specialized focused collections.
Additionally, we offer screening of our proprietary Natural Product Library containing more than 200K compounds.
Hit Identification Support
Inte:Ligand has developed powerful algorithms for generating reliable, accurate and selective pharmacophore models. We use such custom-built models to support our customers with virtual screening of our ultra-large libraries of compounds originating from first-class providers in order to identify well suited hits for their targets.
Our tools, our experience of many years and extensive validation procedures guarantee the high quality of our workflows for identification of hits, which we create on behalf of our clients based on their project needs.
Hit to Lead and Lead Optimization
We offer services to develop accurate and sensitive models to establish in silico SAR to support virtual screening campaigns to identify high quality hits according to your target product profile. Together with premium partners for high-quality chemistry services, we offer tailored hit to lead and lead optimization programs. Our partners are supported by Inte:Ligand's superior in silico decision support tools.
Generation of Customized Virtual Compound Libraries
Focused compound libraries are the key to success in combinatorial chemistry and high throughput screening. Inte:Ligand has developed software for the generation of customized virtual compound libraries with high drug-likeness using generative AI and other approaches.
Different algorithms elaborated for virtual library generation enable us to provide a broad range of diverse ideas for lead structures and subsequently optimized drug-candidates for a specific and well-investigated mode of action for our customers in the pharmaceutical industry.
Target Prediction, Compound Profiling and De-Risking
Pharmacophore-based in-silico screening is an efficient and well established method for profiling and de-risking compound collections. Using our IL PharmDB we can help identify potential targets from phenotypic screening results.
Furthermore, we can assemble data sets to help you with in silico selectivity profiling to help you with hit prioritization and lead optimization.
Furthermore, in silico toxicity and ADMET collections can assist with identifying molecular initiating events leading to toxic adverse outcomes. Using these models, we can profile our customers hit or lead compounds in order to de-risk them.
In addition, Inte:Ligand's pharmacophore development technology offers rapid access to multiple interaction site models for a wide variety of biologically relevant targets, which can be used for establishing desired affinity profiles.
By combining Inte:Ligand's research solutions we can prioritize hits or leads from high throughput screening, assess risks of side effects early and therefore rapidly identify interesting lead structures for our customers.